Influence of Hyperventilation Upon rCBF in the White Matter, with Mass Lesions
AbstractHyperventilation is a well known method of reducing raised ICP and has been used widely in clinical practice. The mechanism of reducing ICP is believed to be due to the cerebrovascular...
View ArticleCloning and Expression in E. coli of the Whole nif Genes of Klebsiella...
AbstractK. oxytoca NG13 is a nitrogen fixer isolated from rhizosphere of rice in Japan, we found that NG13 has a nif gene cluster similar to that of K. pneumoniae M5al, by Southern hybridization. We...
View ArticleK252a: A new blocker of the cell-cycle at G1 phase in a human hepatoma cell line
AbstractThe administration of 200 nM K252a to HuH7 suppressed the proliferation of the cells almost completely. The uptake of [3H]thymidine was inhibited, and flow cytometry revealed only one peak at...
View ArticleSecretion by Saccharomyces cerevisiae of rat apolipoprotein E as a fusion to...
AbstractAs the first step for production of rat apolipoprotein E (rApoE) in Saccharomyces cerevisiae, the rApoE cDNA was cloned and its nucleotide sequence was determined. When the intact rApoE gene...
View ArticleIntegrative transformation of the zygomycete Rhizomucor pusillus by...
Abstract For development of a homologous transformation system for the zygomycete fungus, Rhizomucor pusillus, the isopropylmalate isomerase (leuA) gene was cloned from R. pusillus IFO 4578 by the...
View ArticleGenes, enzymes and secondary metabolites in industrial microorganisms The...
AbstractApparently contrasting aproaches, ie genetic engineering and screening of new microorganisms, play essential complementary roles to develop current industrial microbiology. Three topics,...
View ArticleChromosomal deletions in Streptomyces griseus that remove the afsA locus
Abstract We have recently constructed a physical map of the Streptomyces griseus 2247 genome using the restriction enzymes AseI and DraI, which revealed that this strain carries a 7.8 Mb linear...
View ArticleOverexpression of high-molecular-mass nitrile hydratase from Rhodococcus...
Abstract High-molecular-mass nitrile hydratase (H-NHase, 530 kDa) is a cobalt-containing enzyme produced by Rhodococcus rhodochrous J1. For efficient production of H-NHase in R. rhodochrous ATCC12674,...
View ArticleEvaluation of the malignancy of glioma using 11C-methionine positron emission...
Abstract 11C-methionine positron emission tomography (PET) and proliferating cell nuclear antigen (PCNA) staining were performed in 13 cases of glioma to investigate the relationship between the uptake...
View ArticleA Case of Subcortical Meningioma
Summary¶ Subcortical meningioma, which has been reported as meningioma without dural attachment, a cerebral subcortical lesion, is extremely rare. Very few findings of radiological examination of...
View ArticleBrain PET and technetium-99m-ECD SPECT imaging in Lhermitte-Duclos disease
AbstractTwo patients with Lhermitte-Duclos disease were evaluated by brain positron emission tomography (PET) and technetium-99m-ethyl cysteinate dimer (99mTc-ECD) single-photon emission computed...
View ArticleDevelopment of a membrane dialysis bioreactor and its application to a...
Abstract. A simple membrane dialysis bioreactor was developed for a large-scale axenic culture of Symbiobacterium thermophilum, a symbiotic thermophile that requires co-cultivation with an associating...
View ArticleEffective extracellular trehalose production by Cellulosimicrobium cellulans
AbstractA bacterium isolated from a petal of Casa Blanca Lily (ST26 strain) produced a marked amount of extracellular trehalose (α-d-glucopyranosyl-[1,1]-α-d-glucopyranose) in culture medium containing...
View ArticleApatite-forming ability of alginate fibers treated with calcium hydroxide...
AbstractCalcium alginate fibers were prepared by extruding an aqueous sodium alginate solution into an aqueous calcium chloride solution. The fibers were treated with a saturated aqueous calcium...
View ArticleEfficacy and safety of rebamipide liquid for chemoradiotherapy-induced oral...
AbstractBackgroundRecent preclinical and phase I studies have reported that rebamipide decreased the severity of chemoradiotherapy-induced oral mucositis in patients with oral cancer. This...
View ArticleInduction of haem oxygenase-1 by nitric oxide and ischaemia in experimental...
SummaryInduction of haem oxygenase-1 (HO-1) as well as nitric oxide (NO) biosynthesis during tumour growth was investigated in an experimental solid tumour model (AH136B hepatoma) in rats. An...
View ArticleAntiapoptotic effect of haem oxygenase-1 induced by nitric oxide in...
AbstractInduction of haem oxygenase-1 (HO-1) may provide an important protective effect for cells against oxidative stress. Here, we investigated the mechanism of cytoprotection of HO-1 in solid tumour...
View ArticleUpregulation of ERCC1 and DPD expressions after oxaliplatin-based first-line...
AbstractBackground:The updated randomised phase 2/3 FIRIS study demonstrated the noninferiority of IRIS (irinotecan and S-1) to FOLFIRI (irinotecan, folinic acid, and 5-FU) for metastatic colorectal...
View ArticleCD44s signals the acquisition of the mesenchymal phenotype required for...
AbstractBackground:Circulating tumour cells (CTCs) have an important role in metastatic processes, but details of their basic characteristics remain elusive. We hypothesised that CD44-expressing CTCs...
View ArticlemiR-9-3p plays a tumour-suppressor role by targeting TAZ (WWTR1) in...
AbstractBackground:The inactivation of the Hippo pathway lead to TAZ (PDZ-binding motif)/YAP (yes-associated protein) overexpression, and is associated with worse prognostic outcomes in various cancers...
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